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KMID : 1188320130070060696
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Gut and Liver
2013 Volume.7 No. 6 p.696 ~ p.703
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Practical Effect of Sorafenib Monotherapy on Advanced Hepatocellular Carcinoma and Portal Vein Tumor Thrombosis
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Jeong Soung-Won
Jang Jae-Young
Shim Kwang-Yeun
Lee Sae-Hwan
Kim Sang-Gyune
Cha Sang-Woo
Kim Young-Seok
Cho Young-Deok
Kim Hong-Soo
Kim Boo-Sung
Kim Kyoung-Ha
Kim Jung-Hoon
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Abstract
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Background/Aims:We investigated the effects of sorafenib monotherapy on advanced hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT) in a clinical setting.
Methods:In total, 143 consecutive patients with unresectable HCC were treated with sorafenib. Among these patients, 30 patients with advanced HCC and PVTT (Vp3 or 4) were treated with sorafenib monotherapy.
Results:All patients had a performance status of 1 to 2 (Eastern Cooperative Oncology Group 1/2, 20/10) and Child-Pugh class A or B (A/B, 17/13). Eleven patients had modified Union for International Cancer Control stage IVA tumors, whereas 19 had stage IVB tumors. All patients had PVTT (Vp3, 6; Vp4, 24). Following sorafenib monotherapy, three patients (10.0%) had a partial response with PVTT revascularization, and nine (30.0%) had stable disease, with a disease control rate of 33.3%. The median overall survival was 3.1 months (95% confidence interval [CI], 2.70 to 3.50), and the median progression-free survival was 2.0 months (95% CI, 1.96 to 2.05). Fatigue and hand-foot skin reactions were the most troublesome side effects.
Conclusions:A limited proportion of patients with advanced HCC and PVTT exhibited a remarkable outcome after sorafenib monotherapy, although the treatment results in this type of patient is extremely poor. Further studies to predict good responders to personalized therapy are warranted.
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KEYWORD
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Carcinoma, hepatocellular, Portal vein, Thrombosis, Sorafenib
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